In those CRC cells the APC
Identification of the transcriptional regulatory sequences of human calponin promoter and their use in targeting conditionally replicating herpes vector to malignant human soft tissue and bone tumors. We created transcriptionally targeted oncolytic herpes simplex virus vector bM24TE in which replication is driven by the TE promoter. The WntbetacateninTcell factor Tcf pathway is aberrantly upregulated in the majority of colorectal cancers CRC and hepatoblastomas due to either an APC or betacatenin gene mutation. Intratumoral injection of bM24TE significantly reduced the growth of betacatenininactive A549 tumors. This vector efficiently and specifically replicated in and killed tumor cells with strong betacateninTcf signaling.
Overexpression of Icat induces G2 arrest and cell death in tumor cell mutants for adenomatous polyposis coli, betacatenin, or Axin. Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells. Identification of the transcriptional regulatory sequences of human calponin promoter and their use in targeting conditionally replicating herpes vector to malignant human soft tissue and bone tumors. We created transcriptionally targeted oncolytic herpes simplex virus vector bM24TE in which replication is driven by the TE promoter.
Identification of the transcriptional regulatory sequences of human calponin promoter and their use in targeting conditionally replicating herpes vector to malignant human soft tissue and bone tumors. An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathwaydefective tumors dependence on E1A, the E2F1 promoter, and viral replication for selectivity and efficacy. Our results suggest that transcriptionally regulated oncolytic herpes vector targeting betacateninTcf signal is very efficacious against CRC tumors carrying an APC gene mutation between the first and second 20aminoacid repeats in the mutation cluster region of the APC protein.
An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathwaydefective tumors dependence on E1A, the E2F1 promoter, and viral replication for selectivity and efficacy. In some CRC cell lines, the level of transcription varied considerably among the CRC and hepatoblastoma cell lines. Identification of the transcriptional regulatory sequences of human calponin promoter and their use in targeting conditionally replicating herpes vector to malignant human soft tissue and bone tumors. See all Related Articles….
The WntbetacateninTcell factor Tcf pathway is aberrantly upregulated in the majority of colorectal cancers CRC and hepatoblastomas due to either an APC or betacatenin gene mutation. An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathwaydefective tumors dependence on E1A, the E2F1 promoter, and viral replication for selectivity and efficacy. Overexpression of Icat induces G2 arrest and cell death in tumor cell mutants for adenomatous polyposis coli, betacatenin, or Axin. In those CRC cells, the APC gene mutations were located within small segment between the first and second 20aminoacid repeats.
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